CD8+ T Cells Contribute to the Development of Coronary Arteritis in the Lactobacillus casei Cell Wall Extract-Induced Murine Model of Kawasaki Disease
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- 作者：Magali Noval Rivas ; Youngho Lee ; Daiko Wakita ; Norika Chiba ; Jargalsaikhan Dagvadorj ; Kenichi Shimada ; Shuang Chen ; Michael C. Fishbein ; Thomas J. A. Lehman ; Timothy R. Crother and Moshe Arditi
- 刊名：Arthritis & Rheumatism
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：69
- 期：2
- 页码：410-421
- 全文大小：1119K
- ISSN：1529-0131
文摘
Kawasaki disease (KD) is the leading cause of acquired heart disease among children in developed countries. Coronary lesions in KD in humans are characterized by an increased presence of infiltrating CD3+ T cells; however, the specific contributions of the different T cell subpopulations in coronary arteritis development remain unknown. Therefore, we sought to investigate the function of CD4+ and CD8+ T cells, Treg cells, and natural killer (NK) T cells in the pathogenesis of KD.