Stratification of unresponsive patients by an independently validated index of brain complexity

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• 作者：Silvia Casarotto ; Angela Comanducci ; Mario Rosanova ; Simone Sarasso ; Matteo Fecchio ; Martino Napolitani ; Andrea Pigorini ; Adenauer G. Casali ; Pietro D. Trimarchi ; Melanie Boly ; Olivia Gosseries ; Olivier Bodart ; Francesco Curto ; Cristina Landi ; Maurizio Mariotti ; Guya Devalle ; Steven Laureys ; Giulio Tononi and Marcello Massimini
• 刊名：Annals of Neurology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：80
• 期：5
• 页码：718-729
• 全文大小：553K
• ISSN：1531-8249

文摘

Validating objective, brain-based indices of consciousness in behaviorally unresponsive patients represents a challenge due to the impossibility of obtaining independent evidence through subjective reports. Here we address this problem by first validating a promising metric of consciousness—the Perturbational Complexity Index (PCI)—in a benchmark population who could confirm the presence or absence of consciousness through subjective reports, and then applying the same index to patients with disorders of consciousness (DOCs).