USPIO enhanced lymph node MRI using 3D multi-echo GRE in a rabbit model

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• 作者：Sung Hun Kim ; Soon Nam Oh ; Hyun Seok Choi ; Hyun Sil Lee ; Jaeseop Jun ; Yoonho Nam ; Sung Hak Lee ; Jin-Kwon Lee and Hae Giu Lee
• 刊名：Contrast Media & Molecular Imaging
• 出版年：2016
• 出版时间：November/December 2016
• 年：2016
• 卷：11
• 期：6
• 页码：544-549
• 全文大小：457K
• ISSN：1555-4317

文摘

Ultrasmallsuperparamagnetic iron oxide (USPIO) has been suggested to be a negative MR contrast agent to detect metastatic lymph nodes. Previously reported studies have evaluated the diagnostic performance of USPIO-enhanced MR lymph node imaging based on signal intensity. In this study, we investigate the specific performance of three different parametric approaches (normalized signal intensity, R₂* and susceptibility) using 3D multi-echo gradient echo to quantify the USPIO particles in lymph nodes. Nine rabbits with VX2 tumor implants were scanned before and after USPIO injection. From 3D multi-echo GRE magnitude and phase data, we generated multi-echo combined T₂*-weighted images, an R₂* map, and a quantitative susceptibility map. Eighteen lymph nodes (nine reactive and nine metastatic) were evaluated and showed remarkable signal drops in the area of USPIO accumulation. On parametric analysis, the R₂* difference before and after USPIO injection was significantly different (p < 0.05) between reactive and metastatic lymph nodes; in contrast, the normalized signal intensity and susceptibility were not significantly different between the nodes. Our study showed the potential utility of USPIO-enhanced MRI using R2* mapping from 3D multi-echo GRE for the detection of lymph node metastasis and parametric analysis of lymph node status in a rabbit model. Copyright