Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics

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• 作者：Sang-Bin Lee ; Jung-Woo Kang ; So-Jin Kim ; Jongmin Ahn ; Jinwoong Kim and Sun-Mee Lee
• 刊名：British Journal of Pharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：174
• 期：2
• 页码：195-209
• 全文大小：2097K
• ISSN：1476-5381

文摘

Fulminant hepatic failure (FHF) is a fatal clinical syndrome that results in excessive inflammation and hepatocyte death. Mitochondrial dysfunction is considered to be a possible mechanism of FHF. Afzelin, a flavonol glycoside found in Houttuynia cordata Thunberg, has anti-inflammatory and antioxidant properties. The present study elucidated the cytoprotective mechanisms of afzelin against D-galactosamine (GalN)/LPS induced FHF, particularly focusing on mitochondrial quality control and dynamics.