Xanthones with pancreatic lipase inhibitory activity from the pericarps of Garcinia mangostana L. (Guttiferae)

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• 作者：Hee-Sung Chae ; Eun-Young Kim ; Ling Han ; Na-Rae Kim ; Bunthoeun Lam ; Jin Hyub Paik ; Kee Dong Yoon ; Young Hee Choi and Young-Won Chin
• 刊名：European Journal of Lipid Science and Technology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：118
• 期：9
• 页码：1416-1421
• 全文大小：260K
• ISSN：1438-9312

文摘

Bioactivity-guided isolation of natural compounds from the pericarps of Garcinia mangostana, using a pancreatic lipase assay, led to the identification of 13 xanthones including α-mangostin (1), β-mangostin (2), γ-mangostin (3), 1-isomangostin (4), gartanin (5), garcinone D (6), 9-hydroxycalabaxanthone (7), smeathxanthone A (8), tovophyllin A (9), 8- deoxygartanin (10), mangostanin (11), calocalabaxanthone (12), and 1,7-dihydroxy-3-methoxy-2-(3-methylbut-2-enyl) xanthen-9-one (13). The inhibitory activities of the isolated xanthones against pancreatic lipase were evaluated and α-mangostin (1) was found to possess the most potent inhibitory activity (IC₅₀ 5.0 µM) in a non-competitive manner, compared with the positive control, orlistat (IC₅₀ 3.9 µM).