Touch cytology smear of an inflammatory hepatocellular adenoma displaying an unusual pattern: A case report

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• 作者：Hiroaki Kanda ; Reiko Furuta ; Noriko Motoi ; Naoko Suzuki ; Noriyuki Furuta ; Kyoko Komatsu ; Yuko Sugiyama ; Akio Saiura ; Masahiko Sugitani and Yuichi Ishikawa
• 刊名：Diagnostic Cytopathology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：44
• 期：12
• 页码：1074-1077
• 全文大小：234K
• ISSN：1097-0339

文摘

The cytological diagnosis of hepatocellular adenoma (HCA) is difficult since it is a very rare tumor and lacks characteristic cytological features. We have just reported a case of inflammatory HCA that displayed an unusual histological pattern (Clin J Gastroenterol 8:426–434, 2015). A touch cytology smear sample was obtained from the surgical specimen, and it also exhibited very unique features. A 56-year-old male underwent partial hepatectomy for an inflammatory HCA (diameter: 1.4 cm) in the right posterior lobe of the liver. The cytological sample displayed a characteristic two-cell pattern. One type of cells contained thick cytoplasm, a high nucleus/cytoplasmic (N/C) ratio, and well-defined cytoplasmic borders. The other type demonstrated small pyknotic nuclei and a lower N/C ratio. The immunohistochemical staining pattern of the histological specimen suggested that the latter cells might have been undergoing apoptosis. We report a case of inflammatory HCA with characteristic features. To diagnose this type of variant, it is important to recognize the unique pattern described in this study. Diagn. Cytopathol. 2016;44:1074–1077.