Genetic background of hyperphenylalaninemia in Nagasaki, Japan

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• 作者：Sumito Dateki ; Satoshi Watanabe ; Akiko Nakatomi ; Eiichi Kinoshita ; Tadashi Matsumoto ; Koh-ichiro Yoshiura and Hiroyuki Moriuchi
• 刊名：Pediatrics International
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：58
• 期：5
• 页码：431-433
• 全文大小：146K
• ISSN：1442-200X

文摘

Phenylketonuria (PKU) and related hyperphenylalaninemia (HPA) are caused by a deficiency in hepatic phenylalanine hydroxylase (PAH). The incidence of PKU in Nagasaki prefecture is higher than that in all parts of Japan (1/15 894 vs 1/120 000). To investigate the genetic background of patients with HPA in Nagasaki prefecture, mutation analysis was done in 14 patients with PKU or mild HPA. Homozygous or compound heterozygous PAH mutations were identified in all the patients. The spectrum of PAH mutations in the cohort was broad and similar to those in all parts of Japan and East Asian countries. R53H is the most common mutation in patients with mild HPA. The present results provide further support for genotype–phenotype correlations in patients with HPA. The high incidence of PKU in Nagasaki, the westernmost part of Japan, might be due to migration of people with PAH mutations from China and Korea, and geographic factors.