Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti-hyperalgesic effects, in patients with sciatica
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- 作者：Pieter Okkerse ; Justin L. Hay ; Eve Versage ; Yongqiang Tang ; Gerald Galluppi ; Bernard Ravina ; Ajay Verma ; Leslie Williams ; Ernesto Aycardi and Geert Jan Groeneveld
- 刊名：British Journal of Clinical Pharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：82
- 期：1
- 页码：108-117
- 全文大小：897K
- ISSN：1365-2125
文摘
BG00010 is a protein in the glial cell line-derived neurotrophic factor (GDNF) family. It is a selective ligand for the GDNF family receptor alpha-3 (GFRα3) co-receptor that normalizes cellular changes resulting from damage or disease, and potentially alleviates neuropathic pain. The main objectives of this study were to evaluate the pharmacokinetic and safety profiles and to determine the effects on pain of ascending doses of intravenous injections of BG00010 in patients with sciatica.