Selective Oxytrifluoromethylation of Allylamines with CO2

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• 作者：Jian-Heng Ye ; Lei Song ; Prof. Dr. Wen-Jun Zhou ; Tao Ju ; Zhu-Bao Yin ; Si-Shun Yan ; Zhen Zhang ; Dr. Jing Li and Prof. Dr. Da-Gang Yu
• 刊名：Angewandte Chemie
• 出版年：2016
• 出版时间：August 16, 2016
• 年：2016
• 卷：128
• 期：34
• 页码：10176-10180
• 全文大小：760K
• ISSN：1521-3757

文摘

Reported is the first oxy-trifluoromethylation of allylamines with carbon dioxide (CO₂) using copper catalysis, thus leading to important CF₃-containing 2-oxazolidones. It is also the first time CO₂, a nontoxic and easily available greenhouse gas, has been used to tune the difunctionalization of alkenes from amino- to oxy-trifluoromethylation. Of particular note, this multicomponent reaction is highly chemo-, regio-, and diastereoselective under redox-neutral and mild reaction conditions. Moreover, these reactions feature good functional-group tolerance, broad substrate scope, easy scalability and facile product diversification. The important products could also be formed with either spirocycles or two adjacent tetrasubstituted carbon centers.