Drift tube ion mobility and four-dimensional molecular feature extraction enable data-independent tandem mass spectrometric ‘omics’ analysis without quadrupole selection

详细信息    查看全文

• 作者：Xin Ma ; Jing Liu ; Zhengxiang Zhang ; Tao Bo ; Yu Bai and Huwei Liu
• 刊名：Rapid Communications in Mass Spectrometry
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：33-38
• 全文大小：620K
• ISSN：1097-0231

文摘

Quadrupole-based tandem mass spectrometry (MS/MS) plays a critical role in ‘omics’ studies. However, when a particular m/z precursor is selected by the quadrupole, ions other than the precursor are not transmitted through, and the sensitivity and dynamic range thus diminish. Therefore, separation techniques such as ion mobility (IM) are coupled with MS/MS to improve it.