Validation of the multiplex ligation-dependent probe amplification assay and its application on the distribution study of the major alleles of 17 blood group systems in Chinese donors from Guangzhou

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• 作者：Yanli Ji ; Jizhi Wen ; Barbera Veldhuisen ; Lonneke Haer-Wigman ; Zhen Wang ; Martin Lodé ; n-van Straaten ; Ling Wei ; Guangping Luo ; Yongshui Fu and C. Ellen van der Schoot
• 刊名：Transfusion
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：57
• 期：2
• 页码：423-432
• 全文大小：155K
• ISSN：1537-2995

文摘

Genotyping platforms for common red blood cell (RBC) antigens have been successfully applied in Caucasian and black populations but not in Chinese populations. In this study, a genotyping assay based on multiplex ligation-dependent probe amplification (MLPA) technology was applied in a Chinese population to validate the MLPA probes. Subsequently, the comprehensive distribution of 17 blood group systems also was obtained.