Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma
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- 作者：Yuan-Chiang Chung ; Wan-Chen Wei ; Chia-Nung Hung ; Jen-Fang Kuo ; Chih-Ping Hsu ; King-Jen Chang and Wei-Ting Chao
- 刊名：European Journal of Clinical Investigation
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：46
- 期：12
- 页码：1002-1011
- 全文大小：795K
- ISSN：1365-2362
文摘
Collective cell migration, whereby the cell–cell contacts such as E-cadherin are maintained during migration, has only recently emerged, and its detailed mechanisms are still unclear. In this study, the role of Rab11, which functions in recycling endosomes, and its relationship to E-cadherin in colorectal carcinoma were identified, and the role of Rab11 in the collective cell migration of colon cancer cells was clarified.