Xp11 neoplasm with melanocytic differentiation of the prostate harbouring the novel NONO-TFE3 gene fusion: report of a unique case expanding the gene fusion spectrum
详细信息 查看全文
- 作者：Xiao-tong Wang ; Qiu-yuan Xia ; Hao Ni ; Zi-yu Wang ; Sheng-bing Ye ; Rui Li ; Xuan Wang ; Jing-huan Lv ; Shan-shan Shi ; Heng-hui Ma ; Zhen-feng Lu ; Qin Shen ; Xiao-jun Zhou and Qiu Rao
- 刊名：Histopathology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：69
- 期：3
- 页码：450-458
- 全文大小：1203K
- ISSN：1365-2559
文摘
Recently, an increasing number of TFE3 rearrangement-associated tumours have been reported, such as TFE3 rearrangement-associated perivascular epithelioid cell tumours (PEComas), melanotic Xp11 translocation renal cancers and melanotic Xp11 neoplasms. We have suggested that these tumours belong to a single clinicopathological spectrum. ‘Xp11 neoplasm with melanocytic differentiation’ or ‘melanotic Xp11 neoplasm’ have been proposed to designate this unique neoplasm. Herein, we describe the first case of an Xp11 neoplasm with melanocytic differentiation to be described in the prostate, bearing the novel NONO–TFE3 gene fusion. This study both adds to the spectrum regarding melanotic Xp11 neoplasms and expands its gene fusion spectrum. Moreover, we discuss the relationship of these rare tumours to neoplasms such as conventional PEComas, alveolar soft part sarcomas, malignant melanomas, clear cell sarcomas and Xp11 translocation renal cancers.