Prediagnostic circulating concentrations of plasma insulin-like growth factor-I and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

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• 作者：Aurora Perez-Cornago ; Paul N. Appleby ; Sarah Tipper ; Timothy J. Key ; Naomi E. Allen ; Alexandra Nieters ; Roel Vermeulen ; Sandrine Roulland ; Delphine Casabonne ; Rudolf Kaaks ; Renee T. Fortner ; Heiner Boeing ; Antonia Trichopoulou ; Carlo La Vecchia ; Eleni Klinaki ; Louise Hansen ; Anne Tjø ; nneland ; Fabrice Bonnet ; Guy Fagherazzi ; Marie-Christine Boutron-Ruault ; Valeria Pala ; Giovanna Masala ; Carlotta Sacerdote ; Petra H. Peeters ; H. B(as) Bueno-de-Mesquita ; Elisabete Weiderpass ; Miren Dorronsoro ; J. Ram&oacute ; n Quir&oacute ; s ; Aurelio Barricarte ; Diana Gavrila ; Antonio Agudo ; Signe Borgquist ; Ann H. Rosendahl ; Beatrice Melin ; Nick Wareham ; Kay-Tee Khaw ; Marc Gunter ; Elio Riboli ; Paolo Vineis and Ruth C. Travis
• 刊名：International Journal of Cancer
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：140
• 期：5
• 页码：1111-1118
• 全文大小：165K
• ISSN：1097-0215

文摘

Insulin-like growth factor (IGF)-I has cancer promoting activities. However, the hypothesis that circulating IGF-I concentration is related to risk of lymphoma overall or its subtypes has not been examined prospectively. IGF-I concentration was measured in pre-diagnostic plasma samples from a nested case–control study of 1,072 cases of lymphoid malignancies and 1,072 individually matched controls from the European Prospective Investigation into Cancer and Nutrition. Odds ratios (ORs) and confidence intervals (CIs) for lymphoma were calculated using conditional logistic regression. IGF-I concentration was not associated with overall lymphoma risk (multivariable-adjusted OR for highest versus lowest third = 0.77 [95% CI = 0.57–1.03], p_trend = 0.06). There was no statistical evidence of heterogeneity in this association with IGF-I by sex, age at blood collection, time between blood collection and diagnosis, age at diagnosis, or body mass index (p_{heterogeneity for all} ≥ 0.05). There were no associations between IGF-I concentration and risk for specific BCL subtypes, T-cell lymphoma or Hodgkin lymphoma, although number of cases were small. In this European population, IGF-I concentration was not associated with risk of overall lymphoma. This study provides the first prospective evidence on circulating IGF-I concentrations and risk of lymphoma. Further prospective data are required to examine associations of IGF-I concentrations with lymphoma subtypes.