The utility of ETV1, ETV4 and ETV5 RNA in-situ hybridization in the diagnosis of CIC-DUX sarcomas
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- 作者：Steven C Smith ; Nallasivam Palanisamy ; Elizabeth Martin ; Jorge Almenara ; Jonathan B McHugh ; Eun-Young K Choi ; David R Lucas ; Bryan L Betz ; Dafydd Thomas and Rajiv M Patel
- 刊名：Histopathology
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：70
- 期：4
- 页码：657-663
- 全文大小：4530K
- ISSN：1365-2559
文摘
A recently characterized group of undifferentiated small round cell sarcomas harbours fusions of the genes CIC and DUX4. Studies report a distinctive gene expression profile for these sarcomas, including expression of E26 transformation-specific (ETS) family proto-oncogenic transcription factors ETV1, ETV4 and ETV5. To test the utility of an ancillary diagnostic technique for these tumours, we evaluated chromogenic RNA in-situ hybridization assays for ETV1, ETV4 and ETV5 as diagnostic adjuncts for this emerging group of highly malignant sarcomas.