UGT1A1 (TA)n genotype is not the major risk factor of cholelithiasis in sickle cell disease children
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- 作者：Philippe Joly ; Cé ; line Renoux ; Philippe Lacan ; Yves Bertrand ; Giovanna Cannas ; Nathalie Garnier ; Daniella Cuzzubbo ; Kamila Kebaï ; li ; Cé ; cile Renard ; Alexandra Gauthier ; Vincent Pialoux ; Cyril Martin ; Marc Romana and Philippe Connes
- 刊名：European Journal of Haematology
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：98
- 期：3
- 页码：296-301
- 全文大小：238K
- ISSN：1600-0609
文摘
Because of the increased hemolytic rate, a significant proportion of patients with sickle cell disease (SCD) are prone to develop cholelithiasis. The present study investigated the role of several genetic factors (UGT1A1 promoter (TA)n repeat polymorphism, alpha-globin status), hematological parameters, clinical severity, and hydroxyurea (HU) therapy on the occurrence of cholelithiasis in SCD.