Long non-coding RNA FOXP4-AS1 is an unfavourable prognostic factor and regulates proliferation and apoptosis in colorectal cancer

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• 作者：Juan Li ; Yifan Lian ; Changsheng Yan ; Zeling Cai ; Jie Ding ; Zhonghua Ma ; Peng Peng and Keming Wang
• 刊名：Cell Proliferation
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：50
• 期：1
• 全文大小：1705K
• ISSN：1365-2184

文摘

Despite improvements in diagnosis and treatment, colorectal cancer (CRC) remains the third most common malignancy, and fourth-leading cause of cancer-related death worldwide, and has a particularly high incidence in Western countries. Recent studies have suggested that long non-coding RNAs (lncRNAs) compose a novel class of regulators of cancer biological processes, such as proliferation, apoptosis and metastasis. Here, we report that lncRNA FOXP4-AS1 acts as a functional oncogene in CRC pathogenesis. Moreover, we have attempted to investigate the effects of FOXP4-AS1 on tumour progression, both in vitro and in vivo.