Oxidative Difunctionalization of Alkenyl MIDA Boronates: A Versatile Platform for Halogenated and Trifluoromethylated -Boryl Ketones

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• 作者：Wen-Xin Lv ; Yao-Fu Zeng ; Dr. Qingjiang Li ; Dr. Yunyun Chen ; Dong-Hang Tan ; Ling Yang and Prof.Dr. Honggen Wang
• 刊名：Angewandte Chemie International Edition
• 出版年：2016
• 出版时间：August 16, 2016
• 年：2016
• 卷：55
• 期：34
• 页码：10069-10073
• 全文大小：998K
• ISSN：1521-3773

文摘

The synthesis of halogenated and trifluoromethylated α-boryl ketones via a one-pot oxidative difunctionalization of alkenyl MIDA boronates is reported. These novel densely functionalized organoborons bearing synthetically and functionally valuable carbonyl, halogen/CF₃ and boronate moieties within the same molecule are synthetically challenging for the chemist, but have great synthetic potential, as demonstrated by their applications in a straightforward synthesis of borylated furans. The generality of this reaction was extensively investigated. This reaction is attractive since the starting materials, alkenyl MIDA boronates, are easily accessible.