Photo-induced Carboiodination: A Simple Way to Synthesize Functionalized Dihydrobenzofurans and Indolines

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• 作者：Dr. Xiaobo Yang ; Wenbo Liu ; Dr. Lu Li ; Dr. Wei Wei and Prof. Dr. Chao-Jun Li
• 刊名：Chemistry - A European Journal
• 出版年：2016
• 出版时间：October 17, 2016
• 年：2016
• 卷：22
• 期：43
• 页码：15252-15256
• 全文大小：590K
• ISSN：1521-3765

文摘

Herein, we report a simple, redox-neutral and pH-neutral photo-induced carboiodination reaction under very mild conditions. This protocol employs readily available and cheap aryl bromides and sodium iodide as the starting materials to synthesize valuable functionalized dihydrobenzofurans and indolines in good to excellent yields with broad functional-group compatibility. As examples to demonstrate the utility of this protocol, gram-scale reactions and further transformations of the products were accomplished towards the synthesis of bioactive drug candidates. Most significantly, to the best of our knowledge, this reaction represents the first example of a cascade atom-radical-transfer addition involving the cleavage of aromatic C−Br bond.