A Dipolar Anthracene Dye: Synthesis, Optical Properties and Two-photon Tissue Imaging
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- 作者：Dr. Hyunsoo Moon ; Yong Woong Jun ; Dr. Dokyoung Kim ; Hye Gun Ryu ; Taejun Wang ; Prof. Dr. Ki Hean Kim ; Dr. Youngbuhm Huh ; Prof. Dr. Junyang Jung and Prof. Dr. Kyo Han Ahn
- 刊名：Chemistry – An Asian Journal
- 出版年：2016
- 出版时间：September 20, 2016
- 年：2016
- 卷：11
- 期：18
- 页码：2518-2523
- 全文大小：1030K
- ISSN：1861-471X
文摘
Two-photon microscopy is a powerful tool for studying biological systems. In search of novel two-photon absorbing dyes for bioimaging, we synthesized a new anthracene-based dipolar dye (anthradan) and evaluated its two-photon absorbing and imaging properties. The new anthradan, 9,10-bis(o-dimethoxy-phenyl)-anthradan, absorbs and emits at longer wavelengths than acedan, a well-known two-photon absorbing dye. It is also stable under two-photon excitation conditions and biocompatible, and thus used for two-photon imaging of mouse organ tissues to show bright, near-red fluorescence along with negligible autofluorescence. Such an anthradan thus holds promise as a new class of two-photon absorbing dyes for the development of fluorescent probes and tags for biological systems.