A metabolic way to investigate related hurdles causing poor bioavailability in oral delivery of isoacteoside in rats employing ultrahigh-performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry
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- 作者：Qingling Cui ; Yingni Pan ; Xiaowei Yan ; Bao Qu ; Xiaoqiu Liu and Wei Xiao
- 刊名：Rapid Communications in Mass Spectrometry
- 出版年：2017
- 出版时间：28 February 2017
- 年：2017
- 卷：31
- 期：4
- 页码：371-380
- 全文大小：977K
- ISSN：1097-0231
文摘
Isoacteoside (ISAT), a phenylethanoid glycoside that acts as the principal bioactive component in traditional Chinese medicines, possesses broad pharmacological effects such as neuroprotective, antihypertensive and hepatoprotective activities. However, its pharmaceutical development has been severely limited due to the poor oral bioavailability. It is essential and significant to investigate related hurdles leading to the poor bioavailability of isoacteoside.