Self-Assembly of Multi-nanozymes to Mimic an Intracellular Antioxidant Defense System

详细信息    查看全文

• 作者：Yanyan Huang ; Zhen Liu ; Chaoqun Liu ; Enguo Ju ; Yan Zhang ; Prof. Jinsong Ren and Prof. Xiaogang Qu
• 刊名：Angewandte Chemie
• 出版年：2016
• 出版时间：June 1, 2016
• 年：2016
• 卷：128
• 期：23
• 页码：6758-6762
• 全文大小：1554K
• ISSN：1521-3757

文摘

In this work, for the first time, we constructed a novel multi-nanozymes cooperative platform to mimic intracellular antioxidant enzyme-based defense system. V₂O₅ nanowire served as a glutathione peroxidase (GPx) mimic while MnO₂ nanoparticle was used to mimic superoxide dismutase (SOD) and catalase (CAT). Dopamine was used as a linker to achieve the assembling of the nanomaterials. The obtained V₂O₅@pDA@MnO₂ nanocomposite could serve as one multi-nanozyme model to mimic intracellular antioxidant enzyme-based defense procedure in which, for example SOD, CAT, and GPx co-participate. In addition, through assembling with dopamine, the hybrid nanocomposites provided synergistic antioxidative effect. Importantly, both in vitro and in vivo experiments demonstrated that our biocompatible system exhibited excellent intracellular reactive oxygen species (ROS) removal ability to protect cell components against oxidative stress, showing its potential application in inflammation therapy.