Arterial Stiffness, Central Pulsatile Hemodynamic Load, and Orthostatic Hypotension

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• 作者：Kai Liu ; Si Wang ; Shixi Wan ; Yufei Zhou ; Pei Pan ; Bo Wen ; Xin Zhang ; Hang Liao ; Di Shi ; Rufeng Shi ; Xiaoping Chen and Tulasiram Jangala
• 刊名：The Journal of Clinical Hypertension
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：18
• 期：7
• 页码：655-662
• 全文大小：199K
• ISSN：1751-7176

文摘

The association between central pulsatile hemodynamic load, arterial stiffness, and orthostatic hypotension (OH) is unclear. The authors recruited 1099 participants from the community. Questionnaire, physical examination, and laboratory tests were performed. To assess the correlation between central pulsatile hemodynamic load, arterial stiffness, and OH, multiple logistic regression analysis was performed, and the discriminatory power was assessed by the area under the receiver operating curve. The prevalence of OH in this population was 5.6%. After adjusting for potential confounders, brachial-ankle pulse wave velocity (BaPWV) was significantly and positively correlated with OH in both the hypertension and nonhypertension groups (all P<.05), while central systolic blood pressure (CSBP) was only significantly associated with OH in the hypertension subgroup. In addition, BaPWV seemed to have a better discriminatory power than CSBP in both subgroups. BaPWV appears to be a better indicator of OH than CSBP in routine clinical practice.