A Highly Efficient Copper-Mediated Radioiodination Approach Using Aryl Boronic Acids

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• 作者：Pu Zhang ; Rongqiang Zhuang ; Zhide Guo ; Prof. Xinhui Su ; Prof. Xiaoyuan Chen and Prof. Xianzhong Zhang
• 刊名：Chemistry - A European Journal
• 出版年：2016
• 出版时间：November 14, 2016
• 年：2016
• 卷：22
• 期：47
• 页码：16783-16786
• 全文大小：786K
• ISSN：1521-3765

文摘

A convenient and quantitative radioiodination method by copper-mediated cross-coupling of aryl boronic acids was developed. The mild labeling conditions, ready availability of the boronic acid substrate, simple operation, broad functional group tolerance and excellent radiochemical yield (RCY) make this a practical strategy for radioiodine labeling without further purification.