Mutually exclusive extracellular signal-regulated kinase pathway mutations are present in different stages of multi-focal pulmonary Langerhans cell histiocytosis supporting clonal nature of the disease
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- 作者：Michal Kamionek ; Parnian Ahmadi Moghaddam ; Ali Sakhdari ; Alexandra E Kovach ; Matthew Welch ; Xiuling Meng ; Karen Dresser ; Keith Tomaszewicz ; Ediz F Cosar ; Eugene J Mark ; Armando E Fraire and Lloyd Hutchinson
- 刊名：Histopathology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：69
- 期：3
- 页码：499-509
- 全文大小：1439K
- ISSN：1365-2559
文摘
Pulmonary Langerhans cell histiocytosis (PLCH) is an idiopathic cigarette smoking-related disorder of the lung. Molecular changes in cellular or fibrotic stages of PLCH have not been investigated. We studied the prevalence of extracellular signal-regulated kinase (ERK) pathway mutations in different PLCH stages and other non-PLCH smoking-related lung diseases.