Rare Sesquiterpenoids from the Shed Trunk Barks of the Critically Endangered Plant Abies beshanzuensis and Their Bioactivities
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- 作者：Chang-Ling Hu ; Juan Xiong ; Ji-Yang Li ; Li-Xin Gao ; Wen-Xuan Wang ; Ke-Jun Cheng ; Guo-Xun Yang ; Jia Li and Jin-Feng Hu
- 关键词：Natural products ; Terpenoids ; Beshanzuenones ; Biological activities ; Abies beshanzuensis
- 刊名：European Journal of Organic Chemistry
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：2016
- 期：10
- 页码：1832-1835
- 全文大小：699K
- ISSN：1099-0690
文摘
Two rare rearranged cuparane-type sesquiterpenoid C-10 epimers [beshanzuenones A (1) and B (2)] and two bisabolane-type sesquiterpenoid spirolactones [beshanzuenones C (3) and D (4)] featuring an unusual [6/6/5]-fused tricyclic ring system were isolated from the shed trunk barks of Abies beshanzuensis, one of the critically endangered plant species in the world. The structures of these four new enone-containing sesquiterpenoids were determined by spectroscopic analyses and single-crystal X-ray diffraction or electronic circular dichroism (ECD) calculations. Compounds 1 and 2 showed considerable activity against the H3N2 virus, whereas 3 and 4 exhibited significant inhibition on PTP1B.