Rhodium(II)-Catalysed Skeletal Rearrangement of Ether Tethered N-Sulfonyl 1,2,3-Triazoles: a Rapid Approach to 2-Aminoindanone and Dihydroisoquinoline Derivatives

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• 作者：Yinghua Yu ; Lei Zhu ; Yun Liao ; Zhifeng Mao and Xueliang Huang
• 关键词：aminoindanones ; divergent synthesis ; isoquinolines ; rearrangement reaction ; rhodium carbenes
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2016
• 出版时间：March 31, 2016
• 年：2016
• 卷：358
• 期：7
• 页码：1059-1064
• 全文大小：747K
• ISSN：1615-4169

文摘

The skeletal rearrangement of ether tethered N-sulfonyl-1,2,3-triazoles has been achieved by rhodium(II) catalysis. This method offers a rapid entry to 2-aminoindanone and dihydroisoquinoline architectures which can be further transformed to other valuable building blocks, such as vicinal aminoindanols, isoquinolines and isoquinolinones. A pathway involving an azavinyl rhodium carbene intermediate was proposed according to a preliminary mechanistic study.