Heterogeneity of the resistance to gefitinib treatment in a non-small cell lung cancer patient with active epidermal growth factor receptor mutation

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• 作者：Chong-Rui Xu ; Wen-Zhao Zhong ; Qing Zhou ; Xu-Chao Zhang ; Jin-Ji Yang and Yi-Long Wu
• 刊名：Thoracic Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：51-53
• 全文大小：471K
• ISSN：1759-7714

文摘

We report the case of a 37-year-old male non-small cell lung cancer patient with an active epidermal growth factor receptor (EGFR) mutation who received gefitinib as first-line treatment. After 13.7 months, the patient experienced disease progression and was treated with platinum-based doublet chemotherapy plus gefitinib for 5.4 months. A subsequent lung biopsy showed cMET overexpression; therefore, the patient received a cMET inhibitor with the gefitinib. The response in the different lesions of several organs was diverse. Stable disease was achieved in the lung lesion; however, the liver metastases enlarged. A liver biopsy found T790M mutation in EGFR exon 20, thus, third generation EGFR-tyrosine kinase inhibitors were used and a partial response was achieved.