Direct Catalytic Hydrogenation of Simple Amides: A Highly Efficient Approach from Amides to Amines and Alcohols

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• 作者：Liyang Shi ; Xuefeng Tan ; Jiao Long ; Xiong Xiong ; Song Yang ; Prof. Peng Xue ; Prof. Hui Lv and Prof. Xumu Zhang
• 刊名：Chemistry - A European Journal
• 出版年：2017
• 出版时间：January 12, 2017
• 年：2017
• 卷：23
• 期：3
• 页码：546-548
• 全文大小：585K
• ISSN：1521-3765

文摘

A highly chemoselective and reactive direct catalytic reduction of various amides to amines and alcohols was developed by using a tetradentate ruthenium complex. The catalytic system showed excellent activity (turnover numbers up to 19 600) and great functional group tolerance under mild reaction conditions, compared to several bidentate and tridentate ruthenium-catalyzed systems.