Chemotherapy: Amino Acid Metabolism Abnormity and Microenvironment Variation Mediated Targeting and Controlled Glioma Chemotherapy (Small 40/2016)

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• 作者：Sai An ; Xiuhong Lu ; Weili Zhao ; Tao Sun ; Yu Zhang ; Yifei Lu and Chen Jiang
• 刊名：Small
• 出版年：2016
• 出版时间：October 26, 2016
• 年：2016
• 卷：12
• 期：40
• 页码：5510
• 全文大小：2324K
• ISSN：1613-6829

文摘

The brain requires large amounts of amino acids, which normally get across the brain capillaries through transporters and are then used by brain cells. When glioma takes place, tumor cells sitting right outside brain capillaries are always ready to grab the food of brain cells. Based on this, on page 5633, C. Jiang and co-workers decorate therapeutic nanoparticles with amino acid derivates, making them act as stealth nanoparticles to be swallowed by tumor cells for glioma therapy.