miRNA-34a promotes proliferation of human pulmonary artery smooth muscle cells by targeting PDGFRA

详细信息    查看全文

• 作者：Peng Wang ; Jie Xu ; Zhiling Hou ; Fangfang Wang ; Yingli Song ; Jiao Wang ; Hui Zhu and Hongbo Jin
• 刊名：Cell Proliferation
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：49
• 期：4
• 页码：484-493
• 全文大小：1291K
• ISSN：1365-2184

文摘

Pulmonary arterial hypertension (PAH) is a fast progressing vascular disease characterized by uncontrolled cell proliferation of pulmonary artery smooth muscle cells (PASMCs). Some studies have suggested that PAH and cancers share an apoptosis-resistant state, featuring excessive cell proliferation. The miR-34 family consists of tumour-suppressive miRNAs, and its reduced expression has been reported in numerous cancers; however, its role in hypoxia-induced PAH has not been previously studied.