(C₆F₅)₃B Catalyzed Chemoselective and ortho-Selective Substitution of Phenols with α-Aryl α-Diazoesters

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• 作者：Zhunzhun Yu ; Yongfeng Li ; Jiameng Shi ; Ben Ma ; Prof. Dr. Lu Liu and Prof. Dr. Junliang Zhang
• 刊名：Angewandte Chemie
• 出版年：2016
• 出版时间：November 14, 2016
• 年：2016
• 卷：128
• 期：47
• 页码：15027-15031
• 全文大小：849K
• ISSN：1521-3757

文摘

The development of an efficient method for the site-selective substitution of unprotected phenols has long been considered as an attractive but challenging task. Herein, we describe a highly chemo- and ortho-selective substitution reaction of phenols with α-aryl α-diazoacetates with commercially available (C₆F₅)₃B as the catalyst. This reaction proceeds under simple and mild conditions with high efficiency, it features a wide substrate scope and can be easily scaled up.