Insertion of Isolated Alkynes into Carbon-Carbon σ-Bonds of Unstrained Cyclic β-Ketoesters via Transition-Metal-Free Tandem Reactions: Synthesis of Medium-Sized Ring Compounds

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• 作者：Yuanyuan Zhou ; Xianghua Tao ; Qiyi Yao ; Yulei Zhao and Prof. Dr. Yanzhong Li
• 刊名：Chemistry - A European Journal
• 出版年：2016
• 出版时间：December 12, 2016
• 年：2016
• 卷：22
• 期：50
• 页码：17936-17939
• 全文大小：776K
• ISSN：1521-3765

文摘

The transition-metal-free insertion of isolated alkynes into carbon–carbon σ-bonds of unstrained cyclic β-dicarbonyl compounds has been reported. These tandem reactions offer an efficient synthesis of medium-sized ring or fused-ring compounds through ring expansion. The methodology has the potential to be widely used throughout organic synthesis due to the easily accessible starting materials and mild reaction conditions.