Genome-Wide DNA Methylation Variations upon Exposure to Engineered Nanomaterials and Their Implications in Nanosafety Assessment
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- 作者：Yue Chen ; Ming Xu ; Jie Zhang ; Juan Ma ; Ming Gao ; Zhihong Zhang ; Yong Xu and Sijin Liu
- 刊名：Advanced Materials
- 出版年：2017
- 出版时间：February 10, 2017
- 年：2017
- 卷：29
- 期：6
- 全文大小：3080K
- ISSN：1521-4095
文摘
Sublethal exposure of engineered nanomaterials (ENMs) induces the alteration of various cellular processes due to DNA methylation changes. DNA methylation variations represent a more sensitive fingerprint analysis of the direct and indirect effects that may be overlooked by traditional toxicity assays, and an understanding of the structure–activity relationship of DNA methylation upon ENMs would open a new path for their safer design.