Construction of Chiral Tetraorganosilicons by Tandem Desymmetrization of Silacyclobutanes/Intermolecular Dehydrogenative Silylation
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- 作者：Dr. Qing-Wei Zhang ; Kun An ; Li-Chuan Liu ; Qi Zhang ; Dr. Huifang Guo and Prof. Dr. Wei He
- 刊名：Angewandte Chemie International Edition
- 出版年：2017
- 出版时间：January 19, 2017
- 年：2017
- 卷：56
- 期：4
- 页码：1125-1129
- 全文大小：697K
- ISSN：1521-3773
文摘
We report a method to construct chiral tetraorganosilicons by tandem silacyclobutane (SCB) desymmetrization–dehydrogenative silylations. A wide array of dibenzosiloles with stereogenic quaternary silicon centers were obtained in good yields and enantioselectivities up to 93 % ee. Chiral TMS-segphos was found to be a superior ligand in terms of reactivity and enantioselectivity.