Protective effects of allicin on streptozotocin-induced diabetic nephropathy in rats

详细信息    查看全文

• 作者：Hong Huang ; Ying Jiang ; Genxiang Mao ; Fang Yuan ; Hexin Zheng ; Yuan Ruan and Tianfeng Wu
• 刊名：Journal of the Science of Food and Agriculture
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：97
• 期：4
• 页码：1359-1366
• 全文大小：1338K
• ISSN：1097-0010

文摘

Studies in animal models have shown that allicin, a major biologically active component of garlic, can play a role in the prevention of tissue fibrosis in the liver, lung and heart, mainly related to the inhibition of fibroblast proliferation, fibrogenic cytokine secretion and extracellular matrix synthesis. This study aimed to investigate the protective effects of allicin on renal damage in streptozotocin (STZ)-induced diabetic rats. STZ-induced diabetic rats were administered allicin (15, 30 and 45 mg · kg⁻¹ · day⁻¹) via daily intra-gastric gavage for 12 weeks. The levels of fasting blood glucose (FBG), blood urea nitrogen (BUN), serum creatinine (sCr), lipid and 24 h urine albumin excretion (UAE) were measured at the end of weeks 4, 8 and 12. The renal histopathology and the expression levels of collagen I, transforming growth factor β1 (TGF-β1) and phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2) were measured using immunohistochemistry and/or western blotting.