Effect of FK-506 (tacrolimus) therapy on bone healing of titanium implants: a histometric and biomechanical study in mice

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• 作者：Xiaofei Zheng ; Anchun Mo ; Yuan Wang ; Yuchen Guo ; Yunshu Wu and Quan Yuan
• 刊名：European Journal of Oral Sciences
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：125
• 期：1
• 页码：28-33
• 全文大小：1527K
• ISSN：1600-0722

文摘

Immunosuppressive agents have been recognized as a factor affecting bone metabolism. The aim of the present study was to evaluate the influence of FK-506 administration on the healing of bone around titanium implants. Thirty-two male mice were randomly allocated to two groups: the FK-506 group (n = 16 mice), which received subcutaneous administration of FK-506 (1 mg kg⁻¹ d⁻¹); and the control group (n = 16 mice), which received saline solution by the same route of administration. After 2 wk, one titanium implant with sandblasted/acid-etched surface was placed in the femur. The therapy continued until the mice were killed 2 and 4 wk after surgery. The femurs with implants were evaluated by biomechanical testing and histologic analysis. The bone–implant contact (BIC) and bone volume (BV/TV) within a 100-μm-wide circumferential zone lateral to the implant surface were histomorphometrically analyzed. Compared with the control group, the FK-506 group showed significantly lower BIC and BV/TV at both 2 and 4 wk. Biomechanical tests showed that FK-506 significantly impaired the strength of bone–implant integration at both 2 and 4 wk postoperatively. Our data indicate that immunosuppressive therapy with FK-506 negatively affects the fixation of titanium implants.