Identification of three cannabimimetic indazole and pyrazole derivatives, APINACA 2H-indazole analogue, AMPPPCA, and 5F-AMPPPCA

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• 作者：Wei Jia ; Xin Meng ; Zhenhua Qian ; Zhendong Hua ; Tao Li and Cuimei Liu
• 刊名：Drug Testing and Analysis
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：9
• 期：2
• 页码：248-255
• 全文大小：937K
• ISSN：1942-7611

文摘

This paper reports analytical properties of three cannabimimetic indazole and pyrazole derivatives seized from a clandestine laboratory. These three new synthetic cannabinoids include N-(1-adamantyl)-2-pentyl-2H-indazole-3-carboxamide (APINACA 2H-indazole analogue, 1), N-(1-adamantyl)-4-methyl-1-pentyl-5-phenyl-1H-pyrazole-3-carboxamide (AMPPPCA, 2), and N-(1-adamantyl)-1-(5-fluoropentyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxamide (5F-AMPPPCA, 3). These compounds were identified by liquid chromatography-quadrupole time-of-flight-mass spectrometry (LC-QTOF-MS), gas chromatography-time-of-flight-mass spectrometry (GC-TOF-MS), and nuclear magnetic resonance (NMR) spectroscopy. No analytical properties and pharmacological activities about compounds 1–3 have appeared until now, making this the first report on these compounds. Copyright