Genetic association between NRG1 and schizophrenia, major depressive disorder, bipolar disorder in Han Chinese population

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• 作者：Zujia Wen ; Jianhua Chen ; Raja Amjad Waheed Khan ; Zhijian Song ; Meng Wang ; Zhiqiang Li ; Jiawei Shen ; Wenjin Li and Yongyong Shi
• 关键词：NRG1 ; major depressive disorder ; bipolar disorder ; schizophrenia ; association study
• 刊名：American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：171
• 期：3
• 页码：468-478
• 全文大小：1052K
• ISSN：1552-485X

文摘

Schizophrenia, major depressive disorder, and bipolar disorder are three major psychiatric disorders affecting around 0.66%, 3.3%, and 1.5% of the Han Chinese population respectively. Several genetic linkage analyses and genome wide association studies identified NRG1 as a susceptibility gene of schizophrenia, which was validated by its role in neurodevelopment, glutamate, and other neurotransmitter receptor expression regulation. To further investigate whether NRG1 is a shared risk gene for major depressive disorder, bipolar disorder as well as schizophrenia, we performed an association study among 1,248 schizophrenia cases, 1,056 major depression cases, 1,344 bipolar disorder cases, and 1,248 controls. Totally 15 tag SNPs were genotyped and analyzed, and no population stratification was found in our sample set. Among the sites, rs4236710 (corrected P_genotye= 0.015) and rs4512342 (P_allele= 0.03, P_genotye= 0.045 after correction) were associated with schizophrenia, and rs2919375 (corrected P_genotye= 0.004) was associated with major depressive disorder. The haplotype rs4512342-rs6982890 showed association with schizophrenia (P = 0.03 for haplotype “TC” after correction), and haplotype rs4531002-rs11989919 proved to be a shared risk factor for both major depressive disorder (“CC”: corrected P = 0.009) and bipolar disorder (“CT”: corrected P = 0.003). Our results confirmed that NRG1 was a shared common susceptibility gene for major mental disorders in Han Chinese population.