PD-1 expression on the surface of peripheral blood CD4⁺ T cell and its association with the prognosis of patients with diffuse large B-cell lymphoma

详细信息    查看全文

• 作者：Wei Zhang ; Jie-Fei Bai ; Meng-Xuan Zuo ; Xin-Xin Cao ; Miao Chen ; Yan Zhang ; Xiao Han ; Ding-Rong Zhong and Dao-Bin Zhou
• 刊名：Cancer Medicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：5
• 期：11
• 页码：3077-3084
• 全文大小：438K
• ISSN：2045-7634

文摘

The aim of the study was to investigate the relationship between PD-1 expression on the surface of CD4⁺ T cells and prognosis of patients with diffuse large B-cell lymphoma (DLBCL). Sixty patients who were newly diagnosed with DLBCL and 39 healthy controls were enrolled. In CD4⁺ T cells of DLBCL patients, the median MFI of PD-1 were 541.5 (range: 348.25–758.75), significantly higher than 250 (range: 211–326) in healthy controls (P < 0.001). The ZAP70, PI3K, and NFAT mRNA expression levels of patients were 0.47, 0.47, and 0.62 times, respectively, of those of the healthy controls (P < 0.05). In patients with the percentage of PD-1 on CD4⁺ T cells ≥30.25%, their EFS and OS were significantly lower than patients with PD-1⁺ CD4⁺ T cells <30.25% (P < 0.05). The possible explanation is that high PD-1 expression on CD4⁺ cells of DLBCL patients may impair T-cell function and thus contribute to poor prognosis. There was no relationship between PD-1 surface expression on CD4⁺ T cells and PD-1 expression within the biopsy of tumor microenvironments from DLBCL patients.