Puerarin offsets the anticoagulation effect of warfarin in rats by inducing rCyps, upregulating vitamin K epoxide reductase and inhibiting thrombomodulin
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- 作者：Beikang Ge ; Zhen Zhang ; Teddy Taining Lam and Zhong Zuo
- 刊名：Biopharmaceutics & Drug Disposition
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：38
- 期：1
- 页码：33-49
- 全文大小：1538K
- ISSN：1099-081X
文摘
The current study was conducted to investigate the potential pharmacokinetic and pharmacodynamic interactions between warfarin and puerarin which is the most abundant component in Pueraria lobata (Gegen). In vivo and ex vivo rat models were used to reveal the underlying mechanisms of such interactions.