c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression

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• 作者：R. Wang ; W. Zhang ; Z. Dong ; Y. Qi ; M. Hultströ ; m ; X. Zhou and E. Y. Lai
• 刊名：Acta Physiologica
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：219
• 期：2
• 页码：494-509
• 全文大小：2184K
• ISSN：1748-1716

文摘

Prostaglandin E2 mediates sympathoexcitation in chronic heart failure (CHF) through EP3 receptors (PTGER3) in the paraventricular nucleus (PVN). The aim of this study was to investigate the role of c-Jun N-terminal kinase (JNK) in expressional regulation of gamma-aminobutyric acid signalling in PVN in CHF rats.