Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore
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- 作者：Xiao-Dong Zhang ; Huasen Wang ; Alexander L. Antaris ; Lulin Li ; Shuo Diao ; Rui Ma ; Andy Nguyen ; Guosong Hong ; Zhuoran Ma ; Joy Wang ; Shoujun Zhu ; Joseph M. Castellano ; Tony Wyss-Coray ; Yongye Liang ; Jian Luo and Hongjie Dai
- 刊名：Advanced Materials
- 出版年：2016
- 出版时间：August 24, 2016
- 年：2016
- 卷：28
- 期：32
- 页码：6872-6879
- 全文大小：1578K
- ISSN：1521-4095
文摘
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI.