Quantitative assessment of the association between Fas/FasL gene polymorphism and susceptibility to esophageal carcinoma in a north Chinese population

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• 作者：Meijuan Zhang ; Cuiping Wu ; Baohuan Li ; Wenjun Du ; Chuanzhen Zhang and Ziping Chen
• 关键词：Esophageal carcinoma ; Fas ; FasL ; polymorphism
• 刊名：Cancer Medicine
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：5
• 期：4
• 页码：760-766
• 全文大小：78K
• ISSN：2045-7634

文摘

The case–control study aims to investigate the association of Fas and FasL genetic polymorphisms (Fas-670A/G (rs1800682), Fas-1377G/A (rs2234767) and FasL-844T/C (rs763110)) with esophageal carcinoma susceptibility in a north Chinese population. A total of 204 patients with esophageal carcinoma and 248 healthy controls were enrolled from Henan, China and genotyped by the polymerase chain reaction and restriction fragment length polymorphism method. There were no significant differences in distributions of their genotypes frequencies between patients and controls in Fas-670A/G, Fas-1377G/A and FasL-844T/C polymorphisms (P > 0.05). Stratified analysis showed that no significant association was found between esophageal carcinoma and gene polymorphisms of Fas-670 A/G, Fas-1377G/A, and FasL-844T/C (P > 0.05). Genetic polymorphisms in the death pathway genes Fas and FasL were not associated with risk of developing esophageal carcinoma in a north Chinese population.