Mild hyperglycemia triggered islet function recovery in streptozotocin-induced insulin-deficient diabetic rats

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• 作者：Yu Cheng ; Jing Shen ; Weizheng Ren ; Haojie Hao ; Zongyan Xie ; Jiejie Liu ; Yiming Mu and Weidong Han
• 刊名：Journal of Diabetes Investigation
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：44-55
• 全文大小：1802K
• ISSN：2040-1124

文摘

Moderate elevation of glucose level has been shown to effectively promote β-cell replication in various models in vitro and in normal rodents. Here, we aimed to test the effect of moderately elevated glucose on β-cell mass expansion and islet function recovery in diabetic animal models.