Reparixin attenuates neuronal injury in experimental Klebsiella pneumoniae meningoencephalitis through dual effects on neuroprotection and neuroinflammation

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• 作者：Chien-Tsai Chiu ; Li-Li Wen ; Hsin-Ping Pao ; Ling-Yu Yang ; Ya-Ni Huang and Jia-Yi Wang
• 刊名：Neuropathology and Applied Neurobiology
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：42
• 期：4
• 页码：326-343
• 全文大小：42420K
• ISSN：1365-2990

文摘

Bacterial meningitis causes high mortality and brain damage. The host immune response is associated with brain injury. Chemokine (C-X-C motif) (CXC) chemokines are neutrophil chemoattractants. This study focused on the beneficial effects of intracerebroventricular administration of reparixin, an inhibitor of chemokine (C-X-C motif) receptor (CXCR)1/2, to rats at 2 h following experimental Klebsiella pneumoniae meningoencephalitis.