Four-Component Reaction for the Synthesis of Indolizines by Copper-Catalyzed Aerobic Oxidative Dehydrogenative Aromatization

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• 作者：Juanfang Xu ; Huayou Hu ; Yun Liu ; Xiang Wang ; Yuhe Kan and Chao Wang
• 刊名：European Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 10, 2017
• 年：2017
• 卷：2017
• 期：2
• 页码：257-261
• 全文大小：879K
• ISSN：1099-0690

文摘

A one-pot, four-component reaction was developed for the synthesis of indolizines from pyridines, α-halide carbonyl compounds, primary amines, and maleic anhydride. The key step in this reaction involved the copper-catalyzed aerobic oxidative aromatization of a tetrahydrogen–indolizine intermediate. Oxygen gas was employed as a clean oxidant to facilitate the catalytic process. Notably, this transformation used readily available starting materials, exhibited broad substrate scope, was easy to handle, and required mild reaction conditions.