Palladium-Catalyzed Chemo- and Enantioselective C−O Bond Cleavage of -Acyloxy Ketones by Hydrogenolysis

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• 作者：Dr. Jianzhong Chen ; Dr. Zhenfeng Zhang ; Dr. Delong Liu and Prof. Wanbin Zhang
• 刊名：Angewandte Chemie
• 出版年：2016
• 出版时间：July 11, 2016
• 年：2016
• 卷：128
• 期：29
• 页码：8584-8587
• 全文大小：690K
• ISSN：1521-3757

文摘

A chemoselective C−O bond cleavage of the ester alkyl side-chain of α-acyloxy ketones was realized for the first time by a highly efficient palladium-catalyzed hydrogenolysis (S/C=6000, the highest catalytic efficiency by far). Furthermore, a kinetic resolution of α-acyloxy ketones was first developed by enantioselective hydrogenolysis with good yields and up to 99 % ee.