MicroRNA-130b Ameliorates Murine Lupus Nephritis Through Targeting the Type I Interferon Pathway on Renal Mesangial Cells
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- 作者：Xiao Han ; Yan Wang ; Xiaoyan Zhang ; Yuting Qin ; Bo Qu ; Lingling Wu ; Jianyang Ma ; Zhenyuan Zhou ; Jie Qian ; Min Dai ; Yuanjia Tang ; Edward K. L. Chan ; John B. Harley ; Shiyu Zhou and Nan Shen
- 刊名：Arthritis & Rheumatism
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：68
- 期：9
- 页码：2232-2243
- 全文大小：674K
- ISSN：1529-0131
文摘
Type I interferon (IFN) is a critical pathogenic factor during the progression of lupus nephritis (LN). Although microRNAs (miRNAs) have been shown to control the IFN response in immune cells in LN, the role of miRNAs in resident renal cells remains unclear. We undertook this study to investigate the role of microRNA-130b (miR-130b) in the IFN pathway in renal cells as well as its therapeutic effect in LN.