Efficient Preparation of Alkaloids Polycarpine and Polycarpaurines A and C

详细信息    查看全文

• 作者：Pengbin Guo ; Shuang Yan ; Zeliang Hu ; Weihui Zhuang ; Yan Xiong ; Lanya Zhang ; Ziwen Wang and Qingmin Wang
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：121-124
• 全文大小：586K
• ISSN：1943-5193

文摘

An efficient method for the preparation of alkaloids polycarpine and polycarpaurines A and C via microwave-assisted three-step one-pot reaction as the key step has been developed. This is the first report about the synthesis of polycarpaurines A and C. Starting from commercially available p-methoxybenzaldehyde, polycarpine and polycarpaurine A were obtained over seven steps with 40 and 24 % overall yield, respectively. Polycarpine could convert to polycarpaurine C in 72% yield in the presence of NaHSO₃. The structure of polycarpine and polycarpaurines A and C was confirmed by ¹H NMR, ¹³C NMR, and HRMS.